The Harland & Hollingsworth building on Water and West Streets was once the home of the large ship and railcar builder.  Large windows, two copper clad turrets, and a columned "temple" entrance make this an outstanding building of any in the current Riverfront area.  The backhoe in the background marks the location of the new, to be built, Juniper Bank building.
ING Direct's Headquarters on Orange and Water Streets.  The bank did an outstanding job rehabilitating this building.  On the front (other side) of the building, an I-beam was left protruding 4-5 feet, a nod to the canal warehouses in Amsterdam (the similarities, and the location on Orange Street, the Dutch national color, clinched the site for ING's HQ).
The Grand Opera House on the 800 block of Market Street.  This 1,100 seat theater was built in 1871 by the Free Masons.  The facade is iron, and is one of the few iron faced buildings left in the city.
The former Berger Brothers showroom on lower Market Street.  Parcels, Inc. will be consolidating operations here and will invest one million dollars in improvements.
The former Water works building on 14th Street.  I don't believe the City still uses this building.
From what I understand, the City still uses this facility for water distribution to center city Wilmington.  Water is drawn from the Brandywine from the raceway in Brandywine Park.
The 5th Street elevation of Levy's Jewelry.  The building was once the Central Bank, as noted on the still extant brass plate.  The night drop box also still remains.  It would be interesting to see what the original windows, now bricked over, looked like.